Isaac was probably the son of Thomas and Ann (but probably NOT Ann Holt, married 1810), a Weaver from Bury (perhaps Whitefield where brother Francis and sister Mary were born in 1820 and 1822).
Isaac Mather and Mary Taylor of Unsworth married at Prestwich, Bury in 1836. WARNING: There are two other Mather & Taylor families in Bury (shown here).
In 1838 and 1841 there were two births registered for John Mather, MMN = TAYLOR at Holcombe.
In 1841, Isaac and Mary (both 20), Cotton Weaver were at Nuttall, Holcombe, Bury with no children. Mary's assumed mother Nancy Taylor (55) was living with them.
In 1851, Isaac and Ann (both 35) had Ann (15) and Nancy (5) at Pemhole Place, Bury, Lancashire.
In 1852, James Edward was born in Bury.
In 1882, Isaac Mather, Weaver, was living at Elm, New Hampshire.
In 1890, Isaac was at Women's Aid and Relief Society Hoispital, Young, cor. Willow. He died 28 July 1890, aged 74