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Patrick was born in 1497 in Wedderburn Manor, Berwick, Scotland.  Patrick's father was David Hume and his mother is Isabella Hopringle.  His paternal grandfather was George Hume and his paternal grandmother is Mariota Sinclair; his maternal grandparents are James Hopringle and Elizabeth Murray. He had six brothers and two sisters, named George, David, Alexander, John, Andrew, Robert, Isobel and Mariota.  He is the second youngest of the nine children.

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