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Male Isaiah Burr Click to view Isaiah Burr in the family tree

Isaiah was born after 1742.1   Isaiah's father was Nathaniel Burr and his mother was Hannah Loomis.  His paternal grandparents were Jehue Burr and Elizabeth Cable; his maternal grandparents were Isaac Loomis and Hannah Eggleston. He had a brother and five sisters, and also a sibling of unknown gender, named Nathaniel, Hannah, Anna, Eunice, Miriam, Freelove and Salem.  He was the third oldest of the eight children.1 

1 phelps.FTW @ Tree #0105
Further sources/citations:
World Family Tree Vol. 3, Ed. 1 @ Tree #3669, 3669.ftw