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Appleton was born on January 22nd, 1756 in Holliston, Middlesex, Massachusetts.1   Appleton's father was Joshua Prentiss and his mother is Margaret Prentiss.  His paternal grandparents were Henry Prentice and Elizabeth Rand; his maternal grandfather is Nathaniel Appleton. He had a brother and two sisters, named Appleton, Elizabeth and Margaret. He had three half-brothers and two half-sisters, named Joshua E., Henry, Thomas, Mary and Mary.  He died at the age of 2 on June 16th, 1758.2 

1 Early Vital Records of Middlesex County, Massachusetts to about 1850 @ Holliston 127
2 The History and Genealogy of the Prentice, Prentis and Prentiss Families in New England from 1631 to 1883, Edition: 4th @ 21


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