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Male Isaac S. James Click to view Isaac S. James in the family tree

Isaac S. was born in August 1836.1   Isaac S.'s father was John James and his mother was Malinda Welch.  His maternal grandparents were Osias Welch and Elizabeth Rowland. He had two brothers and five sisters, named William, George W., Mary E., Francis M., Eliza Jane, Sarah A. and Malinda.  He was the third oldest of the eight children.1 

1 5974.ftw
Further sources/citations:
World Family Tree Vol. 2, Ed. 1 @ Tree #5974, 5974.ftw, World Family Tree Vol. 2, Ed. 1 @ Tree #5974