Khuê was born in 1930. Khuê's father was Thái and her mother was Cửu Nguyễn. Her paternal grandparents were Tại and Yên Nguyễn. She had five brothers and three sisters, named Hy, Hạnh, Tý, Thủy, An, Đỏ, Thư and Nhậm. She is the second youngest of the nine children.