Thankfull was born in 1763. Thankfull's father is David ,Jr. Crosby and her mother was Bethia Paddock. Her paternal grandparents were David Crosby and Reliance Hopkins. She had a brother and three sisters, named Peter, Deborah, Bethia and Sarah. She was the second oldest of the five children. She died at the age of 48 on August 30th, 1811.