Zisl was born in 1823. Zisl's father was Itzhak (Isaac) SZEPS and her mother was Tila. Her paternal grandfather was Mayer SZEPS and her paternal grandmother is Unnamed. She had six brothers and a sister, and also a sibling of unknown gender, named Abram, Szmul, Dawid, Jacob, Yossl, Yankel, Czarna and SZEPS. She died at the age of 73 in 1896.