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Male Isaacke Appleton Click to view Isaacke Appleton in the family tree

Isaacke was born in Lt. Waldingfield, Suffolk Co., England.1   Isaacke's father was Thomas Appleton and his mother was Mary Isaacke.  His paternal grandparents were William Appleton and Rose Sexton; his maternal grandparents were Edward Isaacke and Margaret Wheattel. He had four brothers and four sisters, named Thomas, Samuel, Isaac, John, Judith, Mary, Martha and Sarah.  He died on September 14th, 1608.1 

Family Details of Isaacke's family with Mary Cage

1 basel.FTW
Further source/citation:
World Family Tree Vol. 9, Ed. 1 @ Tree #2571