Rene De Savoie & Anna Lascaris 
Rene De and Anna were married in a religious ceremony on February 10th, 1499. They had a son and three daughters, named Honorat II De, Madeleine De, Marguerite De and Isabelle De.
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Children
Honorat II De Savoie
Honorat II De was born about June 4th, 1511. He died on September 20th, 1580 in Pressigny-en-Touraine.