Lucrezia De Borja 
Lucrezia De was born on April 18th, 1480 in Rome, Italy. She died at the age of 39 on June 24th, 1519 in Ferrara, Italy.General Notes
SOURCES: "Ancestors/Descendants of Royal Lines" (Contributors: Manuel Abranches de Soveral, Reynaud de Paysac, H.R. Moser <Burke Peerage>), L. Orlandini, O.Guionneau, L.B. de Rouge, E. Polti, A.Terlinden <Genealogy of the existing British Peerage, 1842, and E. Lodge>) http://geneastar.org.
Lucrezia De and Giovanni were married in a religious ceremony in 1493.
Lucrezia De and Afonso D' were married in a religious ceremony in 1497. They had a son named Rodrigo D'.
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Children
Rodrigo D' Aragon
Rodrigo D' was born on November 1st, 1499 in Rome, Italy. He died at the age of 13 in 1512.
Lucrezia De and Afonso I D' were married in a religious ceremony on February 2nd, 1503. They had two sons named Ercole II D' and Francesco D'.
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Children
Ercole II D' Este
Ercole II D' was born on April 4th, 1508. He died at the age of 51 on October 3rd, 1559.
Francesco D' Este
Francesco D' was born on November 1st, 1516. He died at the age of 61 on February 22nd, 1578.