Isabel Nuñez de Guzmàn

Isabel's father was Alvaro Nuñez de Guzmán and her mother was Juana Espinoza Cuevas Pantoja y Galeazo de Alfaro.  Her paternal grandparents were Pedro Nuñez de Guzmán and Lucía Solier de Guzmán.  She was an only child.

They had a son and a daughter, named Alonso and Juana.