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Male Isaac Owen Click to view Isaac Owen in the family tree

Isaac was born on November 7th, 1702.1   Isaac's father was Isaac Owen and his mother was Sarah Holcombe.  His paternal grandparents were John Owen and Rebecca Wade; his maternal grandparents were Banajah Holcombe and Sarah Eno. He had a brother and five sisters, named Elijah, Deborah, Ann, Anna, Sarah and Rebecca.1 

1 phelps.FTW @ Tree #1353
Further sources/citations:
World Family Tree Vol. 1, Ed. 1 @ Tree #1987, 1987.ftw, World Family Tree Vol. 4, Ed. 1 @ Tree #2812, 2812.ftw