Charles Orland, Dauphin of France (11 October 1492 – 16 December 1495). Her only healthy son, he died of the measles when three years old. Buried at Tours Cathedral.
Francis (August 1493). Anne had become pregnant in late 1492/early 1493, but travelled with her husband from castle to castle; she went into labour during a drive in the forest of Courcelles, and the child was premature and stillborn. Buried at Notre-Dame de Cléry.
Stillborn daughter (March 1494). In her third pregnancy, Anne avoided travel (instead residing in Amboise near the Dauphin). However in February 1494 she accompanied the king to Lyon, where he was preparing to depart for the Italian Wars. After arriving on 15 March, she attended all of the ceremonies; the stress of the occasion caused her to go into premature labour, and the child was stillborn.
Stillborn daughter (March 1495). She had become pregnant again in late 1494, but lost the child soon after.[43]
Charles, Dauphin of France (8 September 1496 - 2 October 1496). His death prompted Anne to withdraw temporarily to Moulins in despair. Buried at Tours Cathedral.
Francis, Dauphin of France (July 1497). He died several hours after his birth. Buried at Tours Cathedral.
Anne of France (20 March 1498). She died on the day of her birth at Château de Plessis-lez-Tours. Buried at Tours Cathedral.