Isaakios II+ Angelos
Isaakios II+ was born about September 1156.  He died on April 12th, 1204.

 Eirene+ Palaiologina
She died in 1185.

 Eirene Maria+ Angelina
Eirene Maria+ was born in 1180 in Constantinople, Turkey.  She died at the age of 28 on August 27th, 1208.

 Alexios IV Angelos
Alexios IV was born in 1182.  He died at the age of 22 on February 8th, 1204.