James Hamilton of Cadzow, Knight, was created Lord Hamilton 28 June 1445 and
surrendered all his lands and baronies for erection into a new barony of
Hamilton, the name used thereafter for the town of Cadzow. His loyalties lay
initially with his Douglas kinsmen, with whose chief he visited Rome in 1450
and Canterbury in 1451, and with whom he joined in the league with the Earls
of Crawford and Ross against James II, but he subsequently moved over to the
King's side to help suppress their revolt. He was rewarded with the office of
sheriff of Lanarkshire 1 July 1455, and on 23 October was granted a new
charter of his lands and baronies. He m 1st (by dispensation of 2 Feb 1440/1)
Euphemia, who d 1468, eldest dtr of Sir Patrick Graham and Eupheme, Countess
of Strathern, and widow of Archibald, 5th Earl of Douglas, and had issue: