Manuel I Komnenos & Eirene Syrikaina 
Manuel I and Eirene were married in a religious ceremony in 1253. They had a son and a daughter, named Ioannes II Megas and N Megale.
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Children
Ioannes II Megas Komnenos
Ioannes II Megas was born in 1262. He died at the age of 35 on August 17th, 1297.