Afonso III D' Este & Isabella De Savoie 
They had a son and a daughter, named Francesco I D' and Anna Beatrice D'.
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Personal Details
Afonso III D' Este
Afonso III D' was born on October 22nd, 1591. He died at the age of 52 on May 24th, 1644.
Isabella De Savoie
Isabella De was born on March 11th, 1591. She died at the age of 35 on August 22nd, 1626.
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Children
Francesco I D' Este
Francesco I D' was born on September 6th, 1610 in Modena. He died at the age of 48 on October 14th, 1658.
Anna Beatrice D' Este
Anna Beatrice D' was born in 1626. She died at the age of 64 on September 25th, 1690.