Tjuyu (sometimes transliterated as Thuyu) was an Egyptian noblewoman and descendant of Ahmose-Nefertari[citation needed]. She was the wife of Yuya, a powerful Egyptian courtier of the Eighteenth dynasty of Egypt.
They were the parents of Tiye, wife of Amenhotep III and mother of Akhenaten. Theory also suggests them as possible parents of Ay.
Together with her husband, Tjuyu was buried in the Valley of the Kings, in KV46, where their largely unpillaged remains were found in 1905. It was the best-preserved tomb discovered before that of Tutankhamun