John Brome & Beatrice Shirley 
John and Beatrice were married in a religious ceremony.1 They had three sons and three daughters, and also a child of unknown gender, named Nicholas, Thomas, John, Isabel, Elizabeth, Agnes and Jocosa.
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Children
Isabel Brome
Isabel was born about 1445 in Baddesley Clinton, Warwickshire, England. She died in 1470.
1 GEDCOM File : 2746994.ged @ 55
2 New England Historic and Genealogical Society Register VOLUME CXLII -1988 @ July 1988, Page 243 Maternal Ancestry of Governor Thomas Dudley
2 New England Historic and Genealogical Society Register VOLUME CXLII -1988 @ July 1988, Page 243 Maternal Ancestry of Governor Thomas Dudley