James III Isham
James III was born about 1755 in Amherst County, Virginia.  He died in 1842 in Boyle, County Kentucky.

 Mary Polly (Polly)
Mary Polly, known as Polly, is no longer alive.

 Michael R. Isham
Michael R. was born on July 4th, 1793 in Virginia.  He died at the age of 78 on October 11th, 1871 in Washington County Kentucky.