‌Jose Estanislao and Maria Juana were married in a religious ceremony in 1836 in , Uruguay.  They had four sons and ten daughters, named Jose Manuel, Juan Antonio, Juan Faustino, Pedro Estanislao, Juana Josefa, Teresa Fortunata, Rufina ("Rufa") Segunda, Rosa Del Tra Nsito, Juana Irene, Tiburcia Alejandra, Ma Xima ("Maximiliana") Eladia, Dolores Del Carmen, Matilde and Mercedes.