Liis was born in 1757. Liis' father was Ado and her mother was Mari. Her paternal grandparents were Paap and Anu; her maternal grandparents were Andres and Epp. She had five brothers and five sisters, named Mats, Ado, Jaak, Jüri, Peep, Kärt, Eva, Ann, Anu and Tiiu. She had two half-sisters named Mai and Liis. She died at the age of 45 in 1802.